CBD isolate will have a shelf life of 2 years. This, of course, can vary based on several factors. Things like exposure to light or heat will decrease this shelf life. In some cases, such as with brownies, the shelf life may be significantly shorter due to other ingredients besides CBD contained in that type of product.CBD isolate will have a shelf life of 2 years. This, of course, can vary based on several factors. Things like exposure to light or heat will decrease this shelf life. In some cases, such as with brownies, the shelf life may be significantly shorter due to other ingredients besides CBD contained in that type of product.